One of the worst design decisions in the Android Dalvik virtual machine is the 64K method limit (this limit includes all methods in your application and all libraries you link in; note that this is not the same as Facebook's 64K Dalvik Runtime issue. The cryptic compile time error you'll get during a build of your project is:
java.lang.IllegalArgumentException: method ID not in [0, 0xffff]: 65536
This problem will manifest easily if you hook in a few libraries that have a lot of methods, including notably the Google Play Services Library which can suck up 1/3 of this limit. Other libraries that are huge include the Amazon Web Services library and Guava and Protobufs (which you can substitute with Square's Wire to reduce the method count). You can analyze the method count using
dex-method-counts.
Ken's Blog
Android's Horrid 64K DEX Method Limit08/17/2014
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